Fully funded PhD

Vacancy Reference Number

Manchester Bicentenary

Closing Date

6 Jan 2025

Salary

£19,237

Address

School of Biological Sciences The University of Manchester Manchester, UK

Duration

4 years

Epigenetic mechanisms linking maternal inflammation-induced transcriptional changes to adult behavioural impairment in a neurodevelopmental rat model This project has the primary aim to establish the biological and molecular mechanisms that underpin the increased risk for neurodevelopmental disorders following exposure of the developing fetus in utero to maternal inflammation from maternal immune activation following an infection during pregnancy. Major objectives are to identify targets to improve existing treatments, develop novel treatments, and to determine biomarkers that identify susceptible individuals prior to symptom presentation. This is a timely project spanning multiple disciplines while utilizing the most recent experimental techniques with genome-wide assays (e.g. WGBS DNAm/DNAhm) and advanced molecular and cellular approaches.

Further Information

Applicants must have obtained or be about to obtain a First or Upper Second class UK honours degree, or the equivalent qualifications gained outside the UK, in a biological discipline including Biology, Neuroscience and allied fields, Pharmacology, Molecular Biology. Applicants with experience in basic molecular techniques and an interest in neurodevelopment are encouraged to apply.

Contact Details

reinmar.hager@manchester.ac.uk

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